Chateau Lagrange started out life as Maison Noble de Lagrange Monteil as far back as the middle ages. Historical documents mention the vineyard as far back as 1631. During the 18th century, the picturesque estate was the property of Baron de Brane.

The Baron was better known for counting among his holdings, Brane Cantenac and Brane Mouton, which we are more familiar with as Chateau Mouton Rothschild today. When the Baron was in charge of the estate, the wines were sold as Baron St. Julien. Like most Bordeaux vineyards, the property passed through numerous hands. For a time, it belonged to John Lewis Brown who owned Chateau Cantenac Brown in Margaux, as well as Chateau Brown in Pessac Leognan.

However, Chateau Lagrange did not become well-known for producing wine until 1842. That is when the owner, Count Duchatel added a drainage system in the vineyard. This helped improve the wine immensely. While drainage in vineyards is commonplace today, that was very forward-thinking in 1842.

Deep in debt, the owners began breaking up the estate, selling portions of their vineyard to survive. The first major sale took place in 1840. Those sales caused Chateau Lagrange to downsize from its massive 280 hectares to a manageable 157 hectares. That sale would not be the last time Chateau Lagrange reduced their Medoc vineyards.

In 1970, 32 hectares were sold to Chateau Ducru Beaucaillou. Other parcels were sold to Henri Martin for use in Chateau Gloria. By 1983, the remaining holdings of Lagrange were purchased by the large, Japanese company, Suntory from the Cendoya family, who had owned Chateau Lagrange since 1925.